Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70
نویسندگان
چکیده
منابع مشابه
Structural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70
ZAP-70, a cytoplasmic tyrosine kinase required for T cell antigen receptor signaling, is controlled by a regulatory segment that includes a tandem SH2 unit responsible for binding to immunoreceptor tyrosine-based activation motifs (ITAMs). The crystal structure of autoinhibited ZAP-70 reveals that the inactive kinase domain adopts a conformation similar to that of cyclin-dependent kinases and S...
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ژورنال
عنوان ژورنال: Cell
سال: 2007
ISSN: 0092-8674
DOI: 10.1016/j.cell.2007.03.039